Blood Promise Chapter Twenty-Four

Avery was a spirit user. â€Å"Oh shit.† I sat back down on the bed, my mind reeling. I'd never seen it coming. Hell, no one had. Avery had made a good show of being an air user. Each Moroi had a very low level of control in each element. She'd just barely done enough with air to make it seem like that was her specialization. No one had questioned her further because honestly, who would have ever expected another spirit user around? And since she was out of school, she had no reason to be tested anymore or forced to demonstrate her ability. No one was there to call her on it. The more I thought about it, the more the little signs were there. The charming personality, the way she could talk people into anything. How many of her interactions were spirit controlled? And was it possible†¦ was it possible that Adrian's attraction had been compulsion on her part? I had no reason to feel happy about that, but†¦ well, I did. More to the point, what did Avery want with Lissa? Avery compelling Adrian into liking her wasn't too out there. He was good-looking and came from an important family. He was the queen's great-nephew, and although family members of the current monarch could never inherit the throne immediately afterward, he'd have a good future, one that would always keep him in the highest circles of society. But Lissa? What was Avery's game there? What did she have to gain? Lissa's behavior all made sense now-the uncharacteristic partying, weird moods, jealousy, fights with Christian†¦ Avery was pushing Lissa over the edge, causing her to make horrible choices. Avery was using some sort of compulsion to spin Lissa out of control, alienating her and putting her life in danger. Why? What did Avery want? It didn't matter. The why wasn't important. The how was, as in how I was going to get out of here and back to my best friend. I looked down at myself, at the delicate silk dress I wore. Suddenly, I hated it. It was a sign of how I'd been, weak and useless. I hastily took it off and ransacked my closet. They'd taken away my jeans and T-shirt, but I'd at least been allowed to keep my hoodie. I put on the green sweater dress, seeing as it was the sturdiest thing I had, feeling moderately more capable. I slipped the hoodie on over it. It hardly made me feel like a badass warrior, but I did feel more competent. Sufficiently dressed for action, I returned to the living room and started that pacing that tended to help me think better-not that I had any reason to believe I was going to come up with new ideas. I'd been trying to for days and days with no luck. Nothing was going to change. â€Å"Damn it!† I yelled, feeling better with the outburst. Angry, I flounced into the desk chair, amazed that I hadn't simply thrown it against the wall in my frustration. The chair wobbled, ever so slightly. Frowning, I stood up and looked at it. Everything else in this place was state-of-the-art. Odd that I'd have a faulty chair. I knelt down and examined it more closely. There, on one of the legs, was a crack near where the leg joined with the seat. I stared. All of the furniture here was industrial strength, with no obvious joints. I should know, seeing how long I'd beat this chair against the wall when I first arrived. I hadn't even dented it. Where had this crack come from? Slamming it over and over had done nothing. But I hadn't been the only one to hit it. That very first day, I'd fought with Dimitri and come after him with the chair. He'd taken it from me and thrown it against the wall. I'd never paid attention to it again, having given up on breaking it. When I'd later tried cracking the window, I'd used an end table because it was heavier. My strength hadn't been able to damage the chair-but his had. I picked up the chair and immediately slammed it into that diamond-hard window, half-hoping I might kill two birds with one stone. Nope. Both remained intact. So I did it again. And again. I lost track of how many times I slammed that chair into the glass. My hands hurt, and I knew despite my recovery, I still wasn't at full strength. It was infuriating. Finally, on what felt like my gazillionth try, I looked at the chair and saw the crack had grown bigger. The progress renewed my will and strength. I hit and hit, ignoring the pain as the wood bit into my hands. At long last, I heard a crack, and the leg broke off. I picked it up and stared in amazement. The break hadn't been clean. It was splintered and sharp. Sharp enough to be a stake? I wasn't sure. But I knew for a fact that wood was hard, and if I used enough force, I might be able to hit a Strigoi's heart. It wouldn't kill one, but the blow would stun. I didn't know if it'd be enough to get me out of here, but it was all I had now. And it was a hell of a lot more than I'd had one hour ago. I sat back on the bed, recovering from my battle with the chair and tossing the makeshift stake back and forth. Okay. I had a weapon now. But what could I do with it? Dimitri's face flashed in my mind's eye. Damn it. There was no question about it. He was the obvious target, the one I'd have to deal with first. The door suddenly clicked open, and I looked up with alarm. Quickly, I shoved the chair into a dark corner as panic raced through me. No, no. I wasn't ready. I hadn't fully convinced myself to stake him. It was Inna. She carried a tray but didn't wear her usual subservient expression. The brief look she gave me was filled with hate. I didn't know what she had to be pissed off about. It wasn't like I'd caused her any damage. Yet. I strode over like I was going to examine the tray. Lifting the lid, I saw a ham sandwich and french fries. It looked good-I hadn't eaten in a while -but the adrenaline running through me had shoved any appetite I might have to the background. I glanced back up at her, smiling sweetly. She shot me daggers. Don't hesitate, Dimitri had always said. I didn't. I jumped at Inna, throwing her so hard against the floor that her head slammed back. She looked dazed, but quickly recovered and tried to fight back. I wasn't drugged up this time-well, not much-and my years of training and natural strength finally showed themselves again. I pressed my body against her, keeping her firmly in place. Then, I produced the stake I'd had concealed and pressed those sharp points against her neck. It was like being back in the days of pinning Strigoi in alleys. She couldn't see that my weapon was a chair leg, but the sharp points got her attention as I dug them into her throat. â€Å"The code,† I said. â€Å"What is the code?† Her only response was a string of obscenities in Russian. Okay, not a surprise, considering she probably didn't understand me. I flipped through the meager Russian-English dictionary in my head. I'd been in the country long enough to pick up some vocabulary. Admittedly, it was equivalent to a two-year-old's, but even they could communicate. â€Å"Numbers,† I said in Russian. â€Å"Door.† At least, that's what I hoped I said. She said more impolite things to me, her expression defiant. It really was the Strigoi interrogation all over. My stake bit harder, drawing blood, and I forcibly restrained myself. I might question whether I had the strength to pierce a Strigoi heart with this, but severing a human's vein? Cake. She faltered a little, apparently realizing the same thing. Again, I attempted my broken Russian. â€Å"Kill you. No Nathan. Never†¦Ã¢â‚¬  What was the word? The church service came back to me, and I hoped I had it right. â€Å"Never eternal life.† It got her attention. Nathan and eternal life. The things most important to her. She bit her lip, still angry, but her tirade had stopped. â€Å"Numbers. Door,† I repeated. I pushed the stake in harder, and she cried out in pain. At last she spoke, rattling off a series of digits. Russian numbers were something I had memorized pretty solidly, at least. They were essential for addresses and phone numbers. She cited seven numbers. â€Å"Again,† I said. I made her say it three times and hoped I had it. But there was more. I was pretty sure the outer door had a different code. â€Å"Numbers. Door. Two.† I felt like a caveman. Inna stared, not quite getting it. â€Å"Door. Two.† Understanding glinted in her eyes, and she looked mad. I think she'd hoped I wouldn't realize the other door had its own code. More cutting with the stake made her scream seven more numbers. Again, I made her repeat them, realizing I had no way to know if she was telling me the truth at least until I tried the numbers. For that reason, I decided to keep her around. I felt guilty about what I did next, but these were desperate times. In guardian training, I'd been taught both to kill and to incapacitate. I did the latter this time, slamming her head back against the floor and rendering her unconscious. Her expression went slack, her eyelids drooping. Damn. I was reduced to hurting teenage humans. Standing up, I moved to the door and punched in the first set of numbers, hoping I had them right. To my complete and utter astonishment, I did. The electronic lock clicked, but before I could open the door, I just barely made out another click. Someone had unlocked the outer door. â€Å"Shit,† I muttered. I pulled away from the door immediately, picked up Inna's unconscious body, and hurried to the bathroom. I set her in the tub as gently as possible and had just shut the bathroom door when I heard the main door open. I felt the telltale nausea that signaled a Strigoi was nearby. I knew one of the Strigoi could smell a human, and I hoped shutting her away would be enough to mute Inna's scent. I emerged from the hall and found Dimitri in the living room. I grinned at him and ran into his arms. â€Å"You're back,† I said happily. He held me briefly and then stepped back. â€Å"Yes.† He seemed slightly pleased at the greeting, but soon his face was all business. â€Å"Have you made your decision?† No hello. No how are you feeling? My heart sank. This wasn't Dimitri. â€Å"I have more questions.† I went over to the bed and lay down in a casual way, just like we always did. He followed a few moments later and sat on the edge, looking down at me. â€Å"How long will it take?† I asked. â€Å"When you awaken me? Is it instantaneous?† Once more, I launched into an interrogation session. Honestly, I was running out of questions, and at this point, I didn't really want to know the intricacies of becoming Strigoi. I was becoming more and more agitated with each passing moment. I had to act. I had to make use of my fleeting opportunity here. And yet†¦ before I could act, I had to reassure myself that this really wasn't Dimitri. It was stupid. I should know by now. I could see the physical changes. I'd seen his coldness, the brutality. I'd seen him come fresh from a kill. This wasn't the man I'd loved. And yet†¦ for that one fleeting moment earlier†¦ With a sigh, Dimitri stretched out beside me. â€Å"Rose,† he interrupted, â€Å"if I didn't know better, I'd say you were stalling for time.† Yeah, even as a Strigoi, Dimitri knew how I thought and schemed. I realized if I was going to be convincing, I had to stop playing dumb and remember to be Rose Hathaway. I put on a look of outrage. â€Å"Of course I am! This is a big deal. I came here to kill you, and now you're asking me to join you. You think this is easy for me to do?† â€Å"Do you think it's been easy for me to wait this long?† he asked. â€Å"The only ones who get choices are Moroi who willingly kill, like the Ozeras. No one else gets a choice. I didn't get a choice.† â€Å"And don't you regret that?† â€Å"No, not now. Now that I'm who I was meant to be.† He frowned. â€Å"The only thing hurt is my pride-that Nathan forced me and that he acts as though I'm indebted to him. Which is why I'm being kind enough to give you the choice now, for the sake of your pride.† Kind, huh? I looked at him and felt my heart breaking all over again. It was like hearing the news of his death once more. I suddenly grew afraid I might cry. No. No tears. Dimitri always talked about prey and predators. I had to be the predator. â€Å"You're sweating,† he said suddenly. â€Å"Why?† Damn, damn, damn. Of course I was sweating. I was contemplating staking the man I loved-or thought I'd loved. And along with sweat, I was sure I was giving off pheromones of my agitation. Strigoi could smell all of those things, too. â€Å"Because I'm scared,† I whispered. I propped myself up and stroked the edge of his face, trying to memorize all of his features. The eyes. The hair. The shape of his cheekbones. In my imagination, I overlaid the things I remembered. Dark eyes. Tanned skin. Sweet smile. â€Å"I†¦ I think I'm ready, but it's†¦ I don't know. It's such a big thing.† â€Å"It'll be the best decision of your life, Roza.† My breathing was growing rapid, and I prayed he'd think it was because of my fear of being turned. â€Å"Tell me again. One more time. Why do you want to awaken me so badly?† A slightly weary look crossed his face. â€Å"Because I want you. I've always wanted you.† And that's when I knew. I finally realized the problem. He'd given that same answer over and over, and each time, something about it had bothered me. I'd never been able to pinpoint it, though. Now I could. He wanted me. Wanted me in the way people wanted possessions or collectibles. The Dimitri I'd known†¦ the one I'd fallen for and slept with†¦ that Dimitri would have said he wanted us to be together because he loved me. There was no love here. I smiled at him. Leaning down, I kissed him gently. He probably thought I was doing it for the reasons I always did, out of attraction and desire. In truth, it was a goodbye kiss. His mouth answered mine, his lips warm and eager. I held out the kiss a little longer, both to fight back the tears leaking out of my eyes and to lull him into an unsuspecting state. My hand closed around the chair leg, which I'd hidden in my hoodie pocket. I would never forget Dimitri, not for the rest of my life. And this time, I wouldn't forget his lessons. With a speed he wasn't ready for, I struck out and plunged the stake through his chest. My strength was there-sliding the stake past the ribs and straight into his heart. And as I did it, it was like piercing my own heart at the same time.

Brain Cells Function

Speaking to your right foot will not make it stop wiggling. Asking your left arm to bend and scratch your back will not make it follow either no matter how loudly a person asks. However, right feet do stop wiggling and left arms can be made to scratch backs if one thinks and wants the limbs to stop or start moving. This is because people’s movements are not voice-activated but rather are controlled by commands coming from a person’s brain. The brain is the center or meeting place of the human nervous system. Kids Biology described the nervous system as the main power cable of the body.Through it, the brain is able to receive and send messages to all the other body parts. It can command the hand to perform certain movements while senses can tell the brain about the person’s environment and its effects on the person, such as feelings of pain and heat. Basically, the nervous system is like a built-in telephone inside the body which the brain and the rest of the body can use to tell one another what the body should do or not do. According to Kids Biology, the messages sent are in the form of electricity, similar to the email or the internet, only much, much faster.The things pushing along this electricity inside people’s bodies are called neurons. Brain Cell Online explained that neurons are one of the two kinds of cells, the tiny human particles found in the brain. The other one is the glial cell. According to Brain Cell Online, there are more than 100 billion neurons in the brain. However, there are much more glial cells as they account for 90 percent of the brain’s overall cell count. Glial cells act as the support for the neurons which, as mentioned above, are the cells responsible for passing on the messages between the brain and body in the nervous system.Neurons are not limited in the brain region alone; rather, they are found throughout the nervous system. Brain Cell Online credits neurons with storing and processing infor mation from the brain before sending the information to the right receivers, and vice versa. To perform these multiple responsibilities successfully, neurons are equipped with two special projections or cell endings called dendrites and axons. Chudler distinguishes the two as such: Dendrites bring or push nerve information to the cell body, while axons pull or take them away and pass to another cell.Thus, neurons are like chains of information; passing nerve information from one neuron to another until it reaches the brain or the designated body part. According to Chudler, the information being transferred is in the form of chemicals called neurotransmitters, which flow in and pass through neurons by small gaps called the synapse. The opening allows chemicals to move through electrons so as to make the connections for information chains possible. Chudler further explains that a synapse is composed of three parts: a presynaptic end, a postsynaptic end, and the synaptic cleft which is basically the middle part between the ends.Presynaptic ends are neurotransmitter terminals while postsynaptic ends are neurotransmitter receptor sites. An electrical impulse triggers the release of the neurotransmitters into the cleft until it finally reaches the postsynaptic end where they bind themselves with the receptor site. Chudler writes that this binding can alter cell’s excitability that is increasing or decreasing its potential to hype or intensify the cells’ actions and speed up the transmission of the messages or information being passed.Bain cells are obviously important in people’s experience of the environment. As such, problems with the functions and capabilities of one’s nervous system and all its components such as the neurons have turned into the most difficult and incurable diseases like Alzheimer’s syndrome, stroke, and epilepsy. Fortunately, there are studies evidencing the existence of the concept called neurogenesis. Accord ing to the Society of Neuroscience, neurogenesis refers to the human capability of producing new neurons which can integrate themselves to the working brain (1).This phenomenon suggests the exciting possibility of a self-healing brain—one that keeps one from forgetting and treats brain disorders. Everyone is dependent on having a fully-functioning nervous system, from the brain to the senses and to the tiny microscopic neurons for their daily living. It may be difficult to imagine, but people are able to move their bodies and remember people, objects, and events through complex and lighting-fast information transfer inside our bodies’ tiny cells. Works Cited Brain Cell. Brain Cell.2007. 16 March 2009 . Chudler, Eric. â€Å"The Synapse. † Neuroscience for Kids. University of Washington Engineered Biomaterials. 2009. 16 March 2009 . Kids Biology. Nervous System. 2009. 16 March 2009 . Society for Neuroscience. â€Å"Adult Neurogenesis. † Brain Briefings. Jun e 2007. 16 March 2009 .

Effects of the iPhone on the Americans Assignment

Effects of the iPhone on the Americans - Assignment Example In the words of Steve Jobs, he said, â€Å"Today we introduce three innovative products. The first is a widescreen iPod with touch controls. The second is a revolutionary phone and finally a breakthrough internet communication device (VoIP). An iPod, phone, this device will be called the iPhone. Apple will reinvent the phone.† (Seven Years Ago Today, Steve Jobs introduced the iPhone). Apple’s iPhone has reinvented mobile phone technology. iPhone is compatible to integrate with the modified Apple TV that allows for wireless connectivity to the screen. The iPhone offers the best email mobile messaging phone; it offers a full-screen browsing with a multi-touch screen. Any smartphone manufacturer may NIL the revolutionary and innovative screens and the technology with which it is made. iPhone possesses some of the best and amazing features and has easier user adaptability. The iPhone has a smooth, elegant metallic finish, which makes it long lasting and light. In addition, the software features are user-friendly, compatible with other Apple products such as the Mac, iPad and iMac and well-guarded against virus attacks. The iPhone has incorporated advanced technology; 3G enabled, high processing power thus increasing the speed, Wi-Fi support, high-resolution camera and Bluetooth technology (Boudreaux T., Programming the iPhone User Experience. O’Reilly, 2 009 Pp 10-11). People have adapted to the use of iPhone because they are guaranteed of the quality and technology that iPhone possesses. Its multi-functionality is only of the many features that have made people adore the phone. For the first time, consumers had the experience of mobile browsing as if it was web browsing, especially with the pinching and zooming experience. Their mobile safari was a distinct feature of the smartphones. iPhone has advanced innovations appellant to the clientele; use of oft-lost stylus, accelerometers and auto-correcting software keyboard (The iPhone turns Four: How it has Changed us, Jeffrey Sass).  

Peer Review Essay Example | Topics and Well Written Essays - 750 words

Peer Review - Essay Example Though a good paper, the author falls a victim of some of the highlighted mistakes, and, therefore, the quality of the paper has in a way been compromised. In this document, I will review the work so as to analyze its strengths and weaknesses and give my opinion on the nature of the work as a whole. This author, as I had hinted earlier, has done very much to address the points of the prompt. The author discussed all the points except one. The point that is explicitly noted to missing is where the author was required to state whether he/she is a monist, dualist, pluralist, an idealist or a materialist and the reason for being one. This point was one of the primary requirements of the paper, and its omission implies that the quality of the paper, going by the journal requirements, is relatively small. The author, according to my assessment, scored relatively high in the explication of some of the arguments offered by the philosophers and relatively little in others. I would give him the highest score in his elucidation of the arguments of such philosophers as Thales, Democritus, Heraclitus, Plato, Aristotle, and Descartes. The only part where I would have given him a relatively lower score is the explanation that he gives to Pythagoras’ philosophy; it is not convincing at all. The student should have given more information about Pythagoras, for example, he defended pure monotheism and made pupils go through various degrees before he could allow them personal contact (The life and philosophy of Pythagoras). He literarily looks at some of the objects like fire, water, and grass in page 2 of the paper and hurriedly concludes that they are not made up of numbers, and then ends up finding that the philosophy is wrong. He fails to give it the inner eye so as to understand what t he philosopher meant by stating that the universe is made up of numbers. I find his argument on this

Westcan Research Paper Example | Topics and Well Written Essays - 250 words

Westcan - Research Paper Example This may help manager to identify areas deficiency among them for further training (Kirkpatrick & Kirkpatrick, 2010). Additionally, managers should be asked to give out their opinion concerning the kind of training they would like to have in order to ensure training administered to them is relevant and effective (Kirkpatrick & Kirkpatrick, 2010). Also, it is also very vital to seat down with managers and identify areas of deficiencies among them (Author, 2012). This can help managers to design an effective training package (Bramley & Chartered Institute of Personnel & Development, 2003). In above connection, questionnaires should be designed, piloted and administered to managers to gather information on what should be done in order to have effective meetings (Kirkpatrick & Kirkpatrick, 2010).Research indicates that, managers understand the elements of an effective meeting but they don’t practice what they were taught (Author, 2012).Therefore, managers should be encouraged to put the theory they learnt into practice so that they can become effective and efficient (Bramley & Chartered Institute of Personnel & Development, 2003). Conclusively, the identified needs for training should be evaluated by determining the extent at which the training needs have been implemented (Bramley & Chartered Institute of Personnel & Development, 2003). Bramley, P., & Chartered Institute of Personnel and Development. (2003). evaluating training: [from personal insight to organizational performance]. London: Chartered Institute of Personnel and

Film Evaluation Essay Example | Topics and Well Written Essays - 750 words

Film Evaluation - Essay Example e tortured and abducted women, and quest of certain individuals, who benevolently wish to put an end to such heinous practice so that the world can be a better place to live. Casting of the film does not include giant names from the Hollywood film industry, however, collaborative and sincere acting efforts by Kevin Kline, Cesar Ramos, Paulina Gaità ¡n, and Alicja Bachleda-Curus have attempted to provide a realist impression of the horror of the situation that looms heavy over women even in the modern context of human civilization. This film speaks of a world, where women are subjects of sensual pleasure and financial benefit; where a mother does not hesitate to sell her innocent daughter to satisfy her monetary requirements; where believers of God are indulged in the business of human trafficking; where moral corruption is a regular and normal practice. The name of the film, Trade immediately gives a symbolic impression that every aspect of human life has become commoditized and the essential virtues, such as tenderness, emotion, humanity, and valuing relationship have been defeated in comparison to such commoditization. Despite the fact that in the end of the film, the protagonists have received the chance to get back to their dear ones, but the situation of crisis retains and it has also been made clear through the film that unless immediate actions are taken and human beings do not fight against the present situation, the process of denying human entity will continue and they will increasingly remain as the subjects of trade. Story: Story of the film revolves around lives and experiences of Adriana and Jorge, who are brother and sister in their relation. Residing in the Mexico City, while Jorge has become quite a ruffian due to his close association with wrong friends, on the other, he is very much caring towards his sister and loves her truly. However, in the very beginning of the film, it has been shown that the business of human trafficking for sexual slavery

How do teacher salaries affect students Why does it matter than Essay

How do teacher salaries affect students Why does it matter than teachers earn tens of thousands more in some districts than others - Essay Example This translates to schools which have better academic preparation and schools that are inadequately prepared. The disparity is evident with the results high stake tests that low budgeted schools are destined to fail. This issue matter because students are being subject to the same rigorous aptitude examinations and the unfairness in children’s preparatory education shows up in the result of the tests. The high stake tests which Kozol identified as the culprit, really would make inner-city children fail due to their inadequate preparation which resulted from little budget allocation from the government. To keep up, there are schools that adopt drastic measures just to raise test scores whose method can be compared to military schools. This is not helpful because instead of keeping up, children drops out of school not to mention that it damages their psychological well being that some were even crying when they undergo the rigor of ill-budgeted school’s drastic measures. It defeats the purpose of education because students would opt to be out of school than to be subjected to such punitive measures of schools just to keep

Benefits In Achieving Sustainable Water Management Across The Eurozone Essay

Benefits In Achieving Sustainable Water Management Across The Eurozone - Essay Example Many grounds and surface water bodies in EU are yet daunted with high concentrations of phosphorus and nitrogen (Bouraoui et al 2014). Following the EC (2012), there exist doubts that many numbers of water bodies in EU may not reach the required objectives of WFD by 2015 (Kafflis & Butler 2001) This essay will analyze how successfully WFD has been in introducing an ecosystem-oriented approach for EUs water resource management and water policy. Availability of water to agricultural sector places heavy pressure on available water bodies and to contain nutrient pollution still plays a significant threat to lakes, surface, transitional and groundwater quality in EU. Earlier, with the introduction of Nitrates Directive 91/676/EEC/1991, EU was able to minimize nitrogen losses from the agricultural sector and after two decades of the existence of such Directive, EU is successful in preventing in its member states, which have agriculture as their dominant industry such as Belgium, the Nether lands, France, etc. Accordingly the European Council (2010), due to the introduction of 1991 Nitrates Directive, there had been a 55% fall in nitrate concentration trends in EU member states. According to Bouraoui and Grizetti (2011), the Urban Waste Water Directive 1991/271/EEC was successful in minimizing the phosphorus losses to water bodies in Europe and also resulted in a lower magnitude of nitrogen losses(Bouraoui et al 2014:1). The WFD observed that with about three-fourths of EUs drinking-water supplies being derived from the groundwater sources, its prime significance is to guarantee the quality of groundwater. Three unique varieties of monitoring are specified to evaluate the quality status of European waters such as surveillance, supervising or monitoring, operational supervising and investigative supervising (Kallis & Butler 2001).

Religion and Culture Intertwined Essay Example | Topics and Well Written Essays - 1750 words

Religion and Culture Intertwined - Essay Example Like language, religious practices can vary through time, as they reflect the needs of the people, may it be on the intellectual level or spiritual level. Culture, as in arts, politics, economics, and gender norms, also change to reflect the needs of the people. Not only that, religion as a unit of culture greatly affects those other units since religion is a very powerful force. In fact, religion is the major force in major changes in humanity, as faith usually guides most people’s decisions (Neihardt, 2000), like in politics and economy, even if they say it’s completely logical. Thus, one cannot say that religion is separate, or bigger than culture; no one can either say that culture is independent and greater than religion. They are both interrelated and they both affect each other, as demonstrated in this paper. Culture is generally defined as a total of learned, socially transmitted behavior. A society also means a large group of people living in the same territory , independent of other people and having a common culture. Sometimes, societies resist ideas that seem to be threatening to their own values. It’s impossible for societies to be all the same, but there are cultural universals that help societies interact with each other. These universal are modified means to meet the basic need for food, shelter, clothing and reproduction. Examples of cultural universals are marriage, laws, sexual restrictions, folklore, dancing, etc. These actions are understood in almost all kinds of societies, although they are expressed in a variety of ways. Religion is also a cultural universal. 86% of the world population belongs to a certain religion. Religion has been found long ago, over 100,000 years, as soon as civilization started, to provide explanations about origin, purpose and deaths of humans. Religion is a â€Å"societal glue†. It gives a society ultimate values that make up a social system that hold the people together and integrate people as well. The integrative function of religion is especially apparent in preindustrial societies. In these societies, relationships, harvesting of crops, leadership are all governed by religious laws. For example, crops would be blessed by God, sacrificing is done to please the Gods so that the harvest would be plentiful (Neihardt, 2000). These activities rule people’s behavior too, making religion a veritable aspect of culture. This is very evident in Native American culture. Their society was preindustrial. Although it was preindustrial, their culture was quite developed. They have integrated social structures at the time and they also have sophisticated technology. When discussing Native Americans, people have this notion that they are savages. This is untrue; the whole notion developed because the history books were written by the European conquistadors who had that opinion. Native Americans inhabited the Americas before the Europeans came and colonized it. There we re various tribes scattered across America and these tribes have specialties that help them in their activities, like hunting and farming (Neihardt, 2000). They are very diverse. Native American religions bind them together, and although they have many different tribes, their religions are quite similar. The common aspect is dualism. They have one God for their creation story, which is the Creator; and they have different gods per tribe. This creator guides them on how to live their lives, teaches how to behave according to their culture, etc. Other characters in their religion are the deities. These are spirits that control the

Next Generation Air Transportation System (NextGen) Term Paper

Next Generation Air Transportation System (NextGen) - Term Paper Example However, each improvement in the aviation industry has got a ripple effect that brings change all through the industry (Salas and Maurino, 2010). The demands for air travel have continued to grow, resulting to unprecedented growth within the industry. Growth in the aviation industry has resulted to an expanded workforce that has put pressure on aviation companies to reduce training period and quickly train qualified pilots (Salas and Maurino, 2010). At the same time, technological advancement is helping in implementation of highly complex, computerized systems that change the manner pilots and other personnel relate with other aircrafts. Similarly, there have been calls for broad improvements in traffic control system putting more pressure on industry professionals and researchers. All these influences, thus, have had a great impact on the industry and on the human factors. This present paper discusses the impact of NextGen will have on the human factors in the aviation industry. Nex tGen technology Despite program by Next Generation Air Traffic System (NextGen) being merely one of the many vehicles of transformation in aviation industry, presently, it stands for the most remarkable call for transformation in the aviation industry. ... Through the use of this new technology, the NextGen technology is bound to considerably improve service provision. For instance, projections by NextGen estimate that there is the need to reduce clogging in the air transports system of the US (FAA, 2007) NextGen has availed data equipment that has the ability to tap weather sources all over the airspace. This data has also enabled to provide accurate information on what lies ahead for any particular flight. This ability is also remarkably since aircrafts can access timely information from all dimensions (Salas and Maurino, 2010). The human factor through NextGen has totally overhauled earlier and outdated ways used by airspace bodies. This has significantly changed aviation sector since National Airspace System (NAS) of the US has managed to install better traffic loads. Moreover, it has also helped to project better means by reducing gridlock as well as maintaining safety in the aviation department. Essentials and Benefits Fundamenta l measures and improvements that NextGen has applied to refurbish human factor in the aviation sector include the inception of System Wide Information Management, Automatic dependent surveillance-broadcast, Next Generation Data Communications, Next NAS voice switch and Generation Enabled Weather. Through the use of, Automatic dependent surveillance-broadcast (ADS-B), NextGen (GPS) satellite signals offer efficient information to air controllers and pilots. Such information is much accurate and has increased aircraft safety through safe navigation in the sky. Besides, ground safety for airplanes has tremendously improved. In addition, NextGen has improved the human factor by fixing airplanes with special transceivers known as

Hazardous Material Handling Essay Example for Free

Hazardous Material Handling Essay Chemicals are found in all places; they are used to enhance crop production, distill drinking water, and simplify everyday chores. But chemicals can also be hazardous to the environment as well as to humans if released or used inappropriately. These hazards can take place during disposal, use, transportation, storage, or production.   If a chemical is released in harmful amounts or used unsafely, it can cause lifelong health effects, serious injury, death, and damage to homes, buildings, and other property. In the recent years, the Federal Bureau of Investigation publicly announced that terrorists are particularly interested in releasing hazardous material as well as in targeting their containers on American soil. Alarmingly, if terrorists succeed in such an attack in a populated vicinity, the result would be devastating. The number of casualties ensuing from such an attack would be enormous; dwarfing the fatality count in the 911 attacks. Chemical, Biological and Nuclear Agents and Incidents Deadly chemical, biological, and nuclear agents that may be employed by non-state actors or adversarial nations against civilians could cause mass casualties.   Other than calculated terrorist attacks and deliberate employment of NBC weapons during military operations, the hazards could result from the release of toxic radioactive matters, biological agents of operational significance, and industrial chemicals (Mauroni, 2007, p. 290). Basically, chemical incidents are depicted by rapid onset, from minutes to hours, of apparent health indicators. While in cases of radiological and biological incidents, the onset symptoms entails days to weeks, normally with no distinctive indicators. A recent simulation by the U.S. Naval Research Laboratory revealed that if an attack should occur during a political event or other public celebrations, people could die at a rate of more than 100 per second and, within 30 minutes, up to 100,000 people could die (District of Columbia, Office of the Attorney General, 2005, p. 2). Likewise, a 2004 study by the Homeland Security Council found that even under less crowded circumstances, an attack in a metropolitan area would cause 100,000 hospitalizations, 10,000 severe injuries and 17,500 deaths (District of Columbia, Office of the Attorney General, 2005, p. 2). I. Chemical Agents Several types of toxic cyanide compounds may be used in terrorist attacks. Potassium or sodium cyanides are pale yellow-to-white salts that can be easily utilized to poison drinks or food. When combined with chemicals that enhance skin penetration, cyanide salts can be dispersed as a contact poison. Toxic industrial chemicals such as mustard or nerve agents, in contrast, can be utilized in larger amounts to compensate for their inferior toxicity. Initial skin contact results in slight skin irritation, which turns into more acute yellow fluid-filled lesions (U.S. Department of Homeland Security, 2003). Inhalation of mustard causes breathing problems, damages the lungs, and death by suffocation caused by water in the lungs. II. Biological Agents Bacillus anthracis, the bacterium that generates anthrax, is an attractive biological agent for terrorist attacks because it can endure different environmental conditions, and its inhalation could normally result in death. Anthrax can be used to contaminate water or food or disseminated in an aerosol to respectively cause ingestional or inhalational anthrax (U.S. Department of Homeland Security, 2003). III. Radiological and Nuclear Agents and Devices An RDD or radiological dispersal device is designed to cause contamination of radioactive material due to its diffusing function.   A range of radioactive materials could be employed in a RDD, including Cobalt-60, Strontium-90, and Cesium-137 (U.S. Department of Homeland Security, 2003). Use of an RDD by terrorists could result in economic, environmental and health effects, as well as social and political effects. In a nuclear terrorist event, the hazards are nuclear radiation, shock or blast effect, and thermal radiation. Developments on MAZMAT Incidents Approaches Proper sample gathering is significant to preserve sample veracity for laboratory testing, to guarantee chain-of-custody documentation for possible legal actions, and basically to protect those on-site responders and victims (Association of Public Health Laboratories, 2008). Accordingly, in the recent years the laboratory training programs slowly and seriously take in a proactive sample collection seminar, along with familiarization with laboratory testing methods, as well as proficiency testing program. These programs are intended to assure that first responders in the field will be able to accurately use hand-held testing devices, correctly understand test results and develop proper action plan derived from the findings. Moreover, in view of the fact the ability to detect impending terrorism agents is essential to effective and safe emergency response, Hazmat responders are now being trained on how to operate a range of Hazmat detection devices. As the war against terrorism has intensified, the number of technological advances and knowledge in the field of terrorist agent detection has also been improved among Hazmat teams. Conclusion Hazardous materials incidents cover a diversity of possible situations including explosions, transportation accidents, spills, fires, and similar events. Hazards may include chemical reactions, health hazards, toxicity, explosives, radiological hazards, or a combination of any of the said hazards. In view of these, terrorists have a wide range of alternatives of toxic materials and means for attacks. To adequately and safely counteract Hazmat terrorist attacks, Hazmat teams are regularly modernizing, as well as participating in related trainings, as these trainings identify their strengths and weaknesses not only of their respective teams, but how the teams works together when disaster does arise.

Conflicts with White Settlers Essay Example for Free

Conflicts with White Settlers Essay There were many causes of the conflicts that occurred between white settlers and Native Americans. The Europeans who came to the New World in the early years of their exploration found native people who had a complex civilization with a very different culture than the Europeans did. With the clash of these two cultures, conflict was inevitable. Each culture fought to keep theirs alive and dominant. One major cause of conflict was broken treaties and promises with the settlers. This caused a lot of anger on each side. Along with broken treaties, constant invasion on one another’s land was another major cause of the conflicts. Lastly, unfair treatment and trade negotiations were also helping the fights continue. In conclusion, the conflict between Colonists and Indians was due to the Colonists huge greed for power and land. Major Conflicts There were a few major conflicts with Indians that have held a big part in the history of the United States. The French and Indian War was among one of the first most important conflicts with the Native Americans in the history of America. The French and British were split over what land was whose, and the Indians were split. Another war involving Native Americans was Pontiac’s War. With the French eliminated, Native Americans were left alone in their fight against British colonial aggression. The Indians attacked, and fearing more tension between Native Americans and settlers, Englands King George III issued the Proclamation of 1763. This was prohibiting settlement west of the Allegheny Mountains. A few more were the Battle of Point Pleasant and the Revolutionary War even involved Native Americans. As one can see, a big part of the history of the United States of America involves the people who first called it home, Native Americans.

Drug â€excipient Interaction of Anti-tubercular Drugs

Drug –excipient Interaction of Anti-tubercular Drugs Drug –excipient interaction of anti-tubercular drugs and its in-silico evaluation Abstract Isoniazid and Pyrazinamide are the first line anti tubercular drugs. Lactose is mainly used as the excipient in solid dosage forms of isoniazid and pyrazinamide. These drugs contains primary and secondary amino functional group which interacts with lactose by maillard reaction and form adduct. The maillard reaction adducts of isoniazid and pyrazinamide with lactose were synthesized at 60oC in alkaline borate buffer pH 9.2 and characterized by UV, FT-IR, DSC, HPLC and MS. Docking study for in-sillico evaluation of isoniazid-lactose adduct and pyrazinamide-lactose adduct was performed to study its effect on pharmacological activity. The present study shows the presence of incompatibility between isoniazid and pyazinamidewith lactose which leads to loss the therapeutic effect of isoniazid and pyrazinamide. Keywords: isoniazid, pyrazinamide, lactose, maillard reaction, excipient, incompatibility, dosage form. Introduction Excipients are traditionally better known as promoters of degradation than as stabilizers of drug substances (Crowley 1999). Physicochemical and physiological process e.g. stability, physiological pH, gastrointestinal transit time, disintegration, dissolution, permeability and bioavailability can be altered by drug excipient interaction (Jackson, Young et al. 2000). The interactions of drug with excipients can leads to changes in the chemical, physical and therapeutic properties can be termed as incompatibilities (Chadha and Bhandari 2014) and it may cause the drug degradation (Narang, Desai et al. 2012) and loss of pharmacological activity (Patil and Patil 2013). Lactose is most widely used as the excipient in the solid dosage forms. Lactose is available in different form and different grade with different physical characteristics. Lactose is very popular excipient because of low cost and inertness but in other hand lactose have interaction drug with amino functional group i.e. lact ose undergoes maillard [Monajjemzadeh, 2009]The maillard reaction is named Louis Maillard who reported over 80 years ago that some amine and reducing sugars interact each other and forms brown pigments. The first product of this reaction is simple glycosamine (Wirth, Baertschi et al. 1998). In this study, we attempted to explore the modes of interaction and energy binding of the different isomers of isoniazid adduct, pyrazinamide adduct and also study the biological activity of isoniazid adduct and pyrazinamide adduct compare with the help of various molecular modelling techniques. In treatment of tuberculosis, isoniazid and pyrazinamide are key components of first line regimen (Hemanth, Sudha et al. 2012). Isoniazid is chemically isonicotohydrazide and pyrazinamide is chemically pyrazine-2-carboxamide. Isoniazid and pyrazinamide is susceptible for hydrolysis and oxidation interact with excipient particularly carbohydrate and reducing sugars to form hydrazones. The hydrazone is mainly form by the interaction of isoniazid with lactose. There are also reported incompatibilities between lactose and other drugs containing primary and secondary amino functional group (Haywood, Mangan et al. 2005). In this study we were investigated the interaction between lactose with isoniazid and pyrazinamide for that different analytical technique were used and also done the in-sillico evaluation of isoniazid and pyrazinamide. Materials and methods Materials Isoniazid and Pyrazinamide was generously supplied as a gift sample by Macleods Pharmaceuticals Ltd., Wapi (Gujarat), India. Lactose monohydrate was purchased from Merck, Merck specialtiesPvt.Ltd. Mumbai, India. All other chemicals were of high-performance liquid chromatography (HPLC) and analytical grade. Methods Analytical methods UV-visible spectrophotometry The Ultraviolet-visible spectra of Isoniazid, Pyrazinamide and the Isoniazid–lactose adduct, Pyrazinamide-lactose adductwere recorded on a double beam UV-visible spectrophotometer (UV-1700; Shimadzu, Japan). An accurately weighed quantity of about 10 mg of isoniazid, 10 mg of pyrazinamide, 11.66 mg isoniazid-lactose adduct (equivalent to 10 mg isoniazid), 13.33 mg of pyrazinamide-lactose adduct (equivalent to 10 mg pyrazinamide) each dissolved separately in 100 ml of distilled water. From this, one ml of solution was diluted to 10.0 mL with of distilled water to obtain concentration of 10 ppm. All solutionswere scanned in UV-Visible range at 420 and 490 nm (Yates, Jones et al. 2003). Fourier-Transform infrared spectroscopy The Fourier-transform infrared spectroscopy (FTIR) spectra of isoniazid, pyrazinamide, lactose, a isoniazid–lactose physical mixture, pyrazinamide-lactose physical mixture and the isoniazid–lactose adduct, pyrazinamide-lactose were recorded. The spectra were obtained using the diffuse reflectance scan method using KBr on an FT-IR spectrophotometer (IR Affinity 1; Shimadzu, Japan). The scanning range was 400–4000 cm-1. Each sample was scanned 45 times consecutively to obtain FT-IR spectrum. HPLC analysis The HPLC (Gradient) system used for analysis consisted of Agilent Technologies 1200 series equipment, a G1315D quaternary pump, a G1315D diode array detector and a rheodyne injector fitted with a 20  µL loop. Data were recorded and evaluated using the EZChrome Elite software package. Samples were analyzed using LunaC18 column (250 Ãâ€" 4.6 mm i.d. Ãâ€" 5  µm) (Phenomenex) as stationary phase. The mobile phase was water: methanol (95:05, v/v), flow rate of 0.8 mL/min with detection at 266 nm for isoniazid and 269 nm for pyrazinamide. Differential scanning calorimetry Thermal analysis of Isoniazid, pyrazinamide, isoniazid–lactose adduct and pyrazinamide-lactose was performed by differential scanning calorimetry (DSC) using a TA 6000 Mettler toledo thermal analyzer. Individual samples as well as the Maillard adduct (about 2 mg) were weighed in the DSC aluminum pan and were scanned in the temperature range of 25–300 °C. A heating rate of 10 °C/min was used. The thermograms were reviewed for evidence of interaction. Mass Spectrometry The Mass spectrometry was performed using 410 Prostar binary LC with 500 MS with Electro spray Positive ionization and Negative Ionization mode and Mass range is 50-2000 amu. The Isoniazid-lactose, Pyrazinamide-lactose adduct solution dissolved in mobile phase to obtain concentration about 100 µg/mL. In the positive ion mode with electrospray ionization technique, the sample was analyzed. Determination of lactose in pharmaceutical tablet dosage forms The presence of lactose in DOTs tablets was initially examined according to Indian Pharmacopoeia 2007 by taking 5ml saturated solution of tablet powder and then add 5ml 1 M NaOH, Heat and cool at room temperature finally add potassium cupri tatatarate the solution becomes red color shows presence of lactose. Preparation of adduct Sample Prepared in alkaline borate buffer Accurately weighed quantity of Isoniazid 300 mg (equivalent to dose of isoniazid) and 50 mg lactose monohydrate dissolve in alkaline borate buffer pH 9.2 by stirring and ultrasound in 100 ml round bottom flask. In similar way 750 mg pyrazinamide (equivalent to dose of pyrazinamide) was dissolve with 250 mg lactose monohydrate in alkaline borate buffer pH 9.2 in 100 ml round bottom flask. The cleared solutions were refluxed at 600C for 12 hour on water bath. The reaction mixture filtered was diluted with menthol: water (1:1). The adduct was subjected to HPLC analysis (gradient and isocratic run) and Mass spectrometry (LC-MS) analysis. The intensity of brown color was determined was spectrophotometrically after dissolving weighed quantity in distilled water. Docking study The molecular docking tool, GLIDE (Schrodinger Inc., USA) (2006) was used for ligand docking study. The protein preparation was carried out using ‘protein preparation wizard’ in Maestro 9.0. Result UV-Visible spectroscopy The UV-visible absorption spectrum of the isoniazid–lactose adduct and pyrazinamide–lactose adduct had shown an increase in absorption in the visible range as compared with isoniazid and pyrazinamide in distilled water as the solvent. The increased absorption the visible region (brown color) is due to Melanoidins production as the end products of the Maillard reaction as reported earlier (Shen, Tseng et al. 2007). FT-IR spectroscopy The FT-IR absorption patterns of Isoniazid, Pyrazinamide, lactose, Isoniazid–lactose physical mixture immediately after mixing and pyrazinamide-lactose physical mixture immediately after mixing as well as Isoniazid–lactose adduct, Pyrazinamide-lactose adduct were recorded. The peak at 1678 cm−1 in the IR spectrum of Isoniazid-lactose adduct, 1614 cm−1 Pyrazinamide-lactose adduct can be attributed to the imines formation. The peak of N–H bending is present at 1552 cm−1 and 1583 cm-1 in the IR spectrum of Isonizid and Pyrazinamide and its physical mixture respectively. The peak present in spectrum of Isonizid and Pyrazinamide and its physical mixture are absent in Isoniazid-lactose adduct and Pyrazinamide-lactose adduct both these observations support the formation of adduct. The N–H stretching band of secondary amine appears at 3302 cm−1 and at 3292 cm-1 for Isonizid and Pyrazinamide respectively. The peak for the lactose O–H appears at 3522 cm−1 in the infrared spectra of lactose. The peaks for N–H and O–H stretching appear in the spectrum of the physical mixture, but the peak for N–H disappears in the spectrum of the adduct. This may indicate the reaction of the amine with the red ucing sugar, or it may be due overlapping of N–H stretching peak with that of O–H. The FTIR spectra of Isoniazid, Pyrazinamide, Lactose physical mixture, Isoniazid-lactose adduct and Pyrazinamide-lactose adduct shows an interaction between Isoniazid and Pyrazinamide with lactose leading to the formation of a Maillard product (Pavia et al 2009). Differential scanning calorimetry The DSC thermograms show the presence of melting points for isoniazid and pyrazinamide at 171.61ÃŽ ¿C and 189.55 ÃŽ ¿C. The DSC thermogram of lactose shows the peak at 209.83 ÃŽ ¿C. The adduct shows the disappearance of the melting point peak of isoniazid, pyrazinamide, paracetamol and vildagliptine in adduct samples confirms the formation of adduct. Gradient HPLC analysis Initially a gradient run of water and methanol was performed to obtain preliminary information regarding the unknown peaks in maillard reaction products (Shen, Tseng et al. 2007). The mobile phase was optimized to separate the Isoniazid-lactose adduct and Pyrazinamide-lactose adduct was water: methanol (95:05, v/v) with a flow rate 0.8ml/min at ambient temperature. The Isoniazid-lactose adduct and Pyrazinamide-lactose adduct elutes at 3.833min and 1.613 min respectively. The control samples for isoniazid and pyrazinamide (without lactose) were also analyzed which proves method selectivity. Isocratic HPLC analysis The optimized isocratic HPLC analysis of the Isoniazid-lactose adduct and Pyrazinamide-lactose revealed one extra peak that eluted before Isoniazid and Pyrazinamide elution respectively. Performing analysis under same chromatographic parameters, no another peak was observed in control samples. Mass spectrometry The Isoniazid-lactose and Pyrazinamide-lactose adduct dissolve in mobile phase to obtain drug concentration about 100 µg/ml. In the positive ion mode with electrospray ionization technique, the sample was analyzed. The MS spectra show the precursor ion for Isoniazid-lactose adduct and Pyrazinamide-lactose adduct was protonated molecule ([M+H]+) m/z 463.3 and 448.1 respectively. The Isoniazid-lactose adduct and Pyrazinamide-lactose adduct molecular mass was consistent with Isoniazid-lactose adduct and Pyrazinamide-lactose adduct condensation product respectively. The loss of one water molecule from parent leads to maillard-type condensation product. Docking study Isoniazid In docking study, isoniazid shows binding with ARG-38 amino acid in the selected structure of protein (PDB code: 3I6N) and isoniazid-lactose adduct shows binding with ASN-72, SER-69, SER-173, ALA-134 and PRO-132 amino acid in the selected structure of protein (PDB code: 3I6N) as shown in Table No. 1.1. Pyrazinamide Pyrazinamide shows binding with ALA-131 amino acid in the selected structure of protein (PDB code: 3PL1) and pyrazinamide-lactose adduct shows binding with ASP-133 and LEU-131 amino acid in the selected structure of protein (PDB code: 3PL1). Discussion On the above observation difficulties in the formulating a new pharmaceutical dosage form have often experienced because of the interaction between the lactose and active ingredients itself i.e. isoniazid and pyrazinamide. Although the nature and intensity of this interaction may alter the stability, dissolution rate and consequently absorption of the drug and also affect the pharmacological effect. it indicates that such interactions involving in the formation of the complexes and it studied by different analytical techniques. The UV results shows increased absorption in the visible region (brown color) is due to Melanoidins production as the end products of the Maillard reaction as reported earlier in Shen, Tseng et al. 2007. The FTIR spectra of Isoniazid, Pyrazinamide, Lactose physical mixture, Isoniazid-lactose adduct and Pyrazinamide-lactose adduct shows peak of C=N it shows that formation of a Maillard product. HPLC analysis of the Isoniazid-lactose adduct and Pyrazinamide-lactose revealed one extra peak of impurity or maillard reaction product that eluted before Isoniazid and Pyrazinamide elution respectively. The MS spectra show the precursor ion for Isoniazid-lactose adduct and Pyrazinamide-lactose adduct and it has same molecular weight related to maillard-type condensation product. In the docking study of isoniazid adduct and pyrazinamide adduct shows more binding than isoniazid and pyrazinamide but this is pseudo results because this binding present at hydroxyl group and hydroxyl group are responsible for the increase excretion of the isoniazid and pyrazinamide and it may be reduces the therapeutic effect of isoniazid and pyrazinamide. In spite of that analytical study confirm the occurrence of maillard reaction product in lactose containing solid dosage forms of amino functional group containing drugs but lactose is still preferred as excipient in the isoniazid and pyrazinamide containing anti-tubercular formulation i.e. DOT’s. Conclusion The present study reports that antitubercular drugs i.e. isoniazid and pyrazinamide undergoes maillard reaction and that confirmed by UV, FT-IR, HPLC and MS. The docking study of isoniazid adduct and pyrazinamide adduct more binding than isoniazid and pyrazinamide but it is pseudo results pharmacologically the excretion of isoniazid and pyrazinamide increase and it ultimately reduces the therapeutic activity. A drugs- excipient interaction study can be actively used to the advantage of the formulator to increase the bioavailability of the drug. By compiling the data the use of lactose in the formulation of isoniazid and pyrazinamide, secondary amines needs to reconsideration. References: Chadha, R. and S. Bhandari (2014). Drug–excipient compatibility screening—Role of thermoanalytical and spectroscopic techniques. Journal of pharmaceutical and biomedical analysis87: 82-97. Crowley, P. J. (1999). Excipients as stabilizers. Pharmaceutical science technology today2(6): 237-243. Haywood, A., et al. (2005). Extemporaneous isoniazid mixture: stability implications. Journal of Pharmacy Practice and Research35(3): 181. Hemanth, A. K., et al. (2012). Simple and rapid liquid chromatography method for simultaneous determination of isoniazid and pyrazinamide in plasma. SAARC Journal of Tuberculosis, Lung Diseases and HIV/AIDS9(1): 13-18. Indian Pharmacopoeia, (2007). Government of India, Ministry of health and family walefare, published by the Indian Pharmacopoeia Commission, Gaziabad; vol. II III, pp. 658, 478, 628, 1009, 1008. Jackson, K., et al. (2000). Drug–excipient interactions and their affect on absorption. Pharmaceutical science technology today3(10): 336-345. MONAJJEMZADEH, F., HASSANZADEH, D., VALIZADEH, H., SIAHI-SHADBAD, M. R., MOJARRAD, J. S., ROBERTSON, T. A. ROBERTS, M. S. 2009b. Compatibility studies of acyclovir and lactose in physical mixtures and commercial tablets. European Journal of Pharmaceutics and Biopharmaceutics, 73, 404-413. Narang, A. S., et al. (2012). Impact of excipient interactions on solid dosage form stability. Pharmaceutical research29(10): 2660-2683. PAVIA, D. L. 2009. Introduction to spectroscopy, CengageBrain. com Patil, D. D. and C. R. Patil (2013). Modification of pharmacological activity of nebivolol due to Maillard reaction. Pharmaceutical development and technology18(4): 844-851. Petrella, Stà ©phanie Gelus-Ziental, Nathalie Maudry, Arnaud Laurans, Caroline Boudjelloul, RachidSougakoff, Wladimir(2011).Crystal structure of the pyrazinamidase of Mycobacterium tuberculosis: insights into natural and acquired resistance to pyrazinamide.PLoS One,6(1):e15785. Singh, Amit K Kumar, Ramasamy P Pandey, Nisha Singh, Nagendra Sinha, Mau Bhushan, AshaKaur, PunitSharma, SujataSingh, Tej P (2010). Mode of Binding of the Tuberculosis Prodrug Isoniazid to Heme Peroxidases BINDING STUDIES AND CRYSTAL STRUCTURE OF BOVINE LACTOPEROXIDASE WITH ISONIAZID AT 2.7 Ã… RESOLUTION.Journal of biological chemistry, 285(2): 1569-1576. Shen, S.-C., et al. (2007). An analysis of Maillard reaction products in ethanolic glucose–glycine solution. Food chemistry102(1): 281-287. Wirth, D. D., et al. (1998). Maillard reaction of lactose and fluoxetine hydrochloride, a secondary amine. Journal of pharmaceutical sciences87(1): 31-39. Yates, E. A., et al. (2003). Microwave enhanced reaction of carbohydrates with amino-derivatised labels and glass surfaces. Journal of Materials Chemistry13(9): 2061-2063.

Chomsky and Skinner and Theories Of Language Development Essay

Chomsky and Skinner and Theories Of Language Development Many psychologists have studied and researched into how we acquire language. Some have concluded that the ability to learn language is a genetically inherited skill. Others believe that language is learned following birth and is due to environmental factors. This is part of the nature vs. nurture debate. One of the main psychologists who supported the nurture side was B.F Skinner. Skinner is an empiricist. He put forward the idea that children learn language because of the influence of the environment. Skinner believed that parents would provide more attention and pleasurable reactions when the infant made correct sounds or utterances. This way the child would gradually learn to speak and use language. The child would respond to the smiles and approval of the parents. Skinner explained this as operant conditioning; the reinforcement of a random response by a reward. By trial and error the child would learn to communicate. The child would repeat verbal behaviour that was rewarded and drop sounds or speech that did not work in terms of getting a pleasurable response. This is selective reinforcement. Pavlov and his dogs were and excellent example of operant conditioning. Pavlov rang a bell when it was time for the dogs to eat; eventually the dogs associated the bell with food. Each time the bell rang the dogs salivated. On the other hand, N.Chomsky who was a nativist argued that children are born with a language acquisition device (LAD). This meant that humans have a built in mechanism to help them recognise and speak language. Chomsky believed that children simply neede... ...rmal language acquisition early in life. q Sachs reported the case of Jim, whose parents deaf but who was surrounded by spoken language from the television and radio in the hope that he would learn normal language. Jim showed no signs of learning language until a speech therapist took up his case at the age of three. Without the human interaction with the speech therapist there was no sign that Jim would have learned to speak. He needed the interaction before his language ability could develop. q If language development was innate, surely it would develop soon after we are able to control our voices, which is soon after one year of age. It does not explain why language takes a few years to develop. q Chomsky's theory also doesn't explain why there are such large variations in the rate children learn language. Chomsky and Skinner and Theories Of Language Development Essay Chomsky and Skinner and Theories Of Language Development Many psychologists have studied and researched into how we acquire language. Some have concluded that the ability to learn language is a genetically inherited skill. Others believe that language is learned following birth and is due to environmental factors. This is part of the nature vs. nurture debate. One of the main psychologists who supported the nurture side was B.F Skinner. Skinner is an empiricist. He put forward the idea that children learn language because of the influence of the environment. Skinner believed that parents would provide more attention and pleasurable reactions when the infant made correct sounds or utterances. This way the child would gradually learn to speak and use language. The child would respond to the smiles and approval of the parents. Skinner explained this as operant conditioning; the reinforcement of a random response by a reward. By trial and error the child would learn to communicate. The child would repeat verbal behaviour that was rewarded and drop sounds or speech that did not work in terms of getting a pleasurable response. This is selective reinforcement. Pavlov and his dogs were and excellent example of operant conditioning. Pavlov rang a bell when it was time for the dogs to eat; eventually the dogs associated the bell with food. Each time the bell rang the dogs salivated. On the other hand, N.Chomsky who was a nativist argued that children are born with a language acquisition device (LAD). This meant that humans have a built in mechanism to help them recognise and speak language. Chomsky believed that children simply neede... ...rmal language acquisition early in life. q Sachs reported the case of Jim, whose parents deaf but who was surrounded by spoken language from the television and radio in the hope that he would learn normal language. Jim showed no signs of learning language until a speech therapist took up his case at the age of three. Without the human interaction with the speech therapist there was no sign that Jim would have learned to speak. He needed the interaction before his language ability could develop. q If language development was innate, surely it would develop soon after we are able to control our voices, which is soon after one year of age. It does not explain why language takes a few years to develop. q Chomsky's theory also doesn't explain why there are such large variations in the rate children learn language.

Ludwig Van Beethoven Essay -- essays research papers

Ludwig van Beethoven Beethoven's importance lies not only in his work, but also in his life (Tames, 4). Included in my report is proof that Beethoven was one of the greatest composers of the Romantic era. In this proof is a brief description of his life. This will help you understand how he felt when he wrote his music. Also, there will be a description of all his symphonies. On December 16 or 17, 1770, (date uncertain) at 515 (now 20) Bonngasse Bonn, Germany Beethoven, like Mozart, was born into a small family (Comptons, 1). He took his first lessons on March 26, 1778, (Schmit, 10). In 1787, he went to Vienna to study with Mozart, but he went back to Bonn due to the nature of his mother's sickness (Schmit, 15). This would be the composers last visit to Bonn. After his mother's death on July 17, 1787, Beethoven went back to Vienna to study with Hayden in November of 1792, where he lived for 35 years (Tames, 14). He was unsatisfied with Hayden because he was preoccupied and commonly missed many mistakes made by Beethoven (Schmit, 17). Beethoven, then, went to Neffe who himself started composing at the age of 12. In the late 1700's, Beethoven began to suffer from early symptoms of deafness, and by 1802, Beethoven was convinced that the condition was not only permanent but was getting much worse. The cause of his deafness is still uncertain (Comptons, 1). He was determined to prove that deafness was not a handicap to him (Thompson, 25). Beethoven's deafness started to be noticeable, and by 1818 Beethoven was completely deaf (Schmit, 28). In the year of 1812, Beethoven fell in love with the "Eternally Beloved." Nobody knew her name except Beethoven, who did not mention it in any letter or to friends. Under his first patron, Prince Karl Lichnowsky, Beethoven wrote his first symphony. The first symphony was wrote in 1795, and was a set of three Trios. Beethoven believed that his income came from the successful sale of these works, but it actually came from Lichnowsky (Tames, 12). This symphony was reflective of the classical era. He did not publish this symphony until he was 31. In 1802, Beethoven wrote a second symphony. Beethoven named this symphony "Grande Sinfonie" while in Hiligenstadt wh... ...usic. Not only did he create a bridge between the 18th-century classical period and new beginnings of Romanticism, but he started a new era of music. Beethoven's last years were marked with illness. On March 24, 1827, Beethoven died in Vienna. A crowd of almost 30,000 people attended his funeral and burial at Vienna Central Cemetery (Schmit, 31). The bicentennial of his death was celebrated with performances and recordings of all the masters' works (Comptons, 2). At the funeral, Beethoven's friend wrote a moving address which stated: "We, the representatives of an entire nation, come to mourn the passing of the gracious mouth by which music spoke, the man who inherited and enriched the immortal fame of Handel and Bach, of Hayden and Mozart. He was an artist, and who shall stand beside him? Because he shut himself off from the world, they called him hostile and callous... He withdrew from his fellow-men after he had given them everything, and received nothing in return. But until his death, he preserved a father's heart for mankind. Thus he was, thus he died, thus he will live to the end of time!" (Thompson, 46).

National Parks and Air Traffic Essay -- Nature Court Grand Canyon Essa

National Parks and Air Traffic I. Introduction Grand Canyon National Parks attracted 4.5 million visitors in 1999. Of these 4.5 million visitors, about 40% were not Americans - Germans, French, and Japanese led the way. Grand Canyon National Park brings in millions of tourist dollars per year to the region. One of the most popular ways to see the Canyon besides simply driving to the South Rim and spending the day is by airplane or helicopter. About 800,000 people per year fly over the Canyon. In the peak summer periods, there are over 1,000 flights every day. 31 air companies operating out of five states (Arizona, Nevada, California, Utah, and Colorado) operate tours over the Grand Canyon. In 1995, the total air tour revenue was approximately $115.9 million. An average 30-minute helicopter flights costs $100 per person. The air tour companies argue that they provide a needed service to older and handicap people and children, who would otherwise be unable to experience the Canyon. They also say that their use of the Canyon is envi ronmentally-friendly by not contributing to the air pollution, road congestion, vehicle traffic, garbage and crowded vistas that are common every day during the peak summer periods on the South Rim. Opponents to overflights state that the noise intrusion from the constant buzz of air traffic is intolerable for those hikers, campers, and visitors on the ground, trying to enjoy the natural quiet of the Canyon. They also state that because of the sheer volume of air traffic, this form of sight-seeing has become unacceptably dangerous, citing numerous fatal air accidents. II. Background Shortly after airplanes began flying, air tour companies started on the South Rim and in Nevada in the... ...l, Edwin. "Abuzz About Flights Over the Grand Canyon." New York Times 20 October 1996. Murphy, Jamie. "A Bunch of Little Gnats: A droning echo of tourist flights through the Grand Canyon." Time 28 April 1986: 60. National Parks Overflights Act of 1987 Â § 100, 16 U.S.C. Â § 1a-1 (1987). O’Brien, Bob. Our National Parks and the Search for Sustainability. Austin, Texas: University of Texas Press, 1999. Oversight of Grand Canyon Overflights, 1992: Hearing before the Subcommittee on Aviation of the Senate Committee on Commerce, Science, and Transportation, 102nd Congress, 2nd Session (1992). S. 268, The National parks Overflights Act of 1997, 1997: Hearing before the Senate Committee on Commerce, Science, and Transportation, 105th Congress, 1st Session (1997). "U.S. Government Announces Limits on Flights Over Grand Canyon." Arizona Republic 29 March 2000.

Hobson’s Choice – With particular reference to Act 1, show how Brighouse presents a comic but honest view of family life, set in late 19th century Salford

With particular reference to Act 1, show how Brighouse presents a comic but honest view of family life, set in late 19th century Salford. Hobson's choice is an interesting and enjoyable play, which uses a fair amount of comedy to keep the audience engaged. The audience can really connect with the characters, as they are very realistic and are placed in real-life situations. The comic element comes in regularly, in the form of just one-off, funny lines, or even complete comic situations and themes. Although the play is set in late 19th century, the themes are still relevant today, which shows that although some things may evolve over time, people and their opinions are still the same, and so the audience can relate to the play, which is another reason why Hobson's Choice is so enjoyable. â€Å"Hobson's Choice† is proverbial, stemming from the 17th century; to have â€Å"Hobson's choice† is to have no choice at all. I think that understanding this is a key element in understanding the play, as all of the themes of the play arise from one of the main five characters having â€Å"Hobson's choice†. The play is set in late 19th century Salford, which although it does not tell you in the play, the audience can guess immediately, just from the setting. The play begins in Hobson's Boot Shop, which is a clue straight away, as boot shops are not very common today, and have been replaced by shoe shops and trainer shops. Another clue are â€Å"the cane chairs† in front of the counter, where â€Å"the ordinary people sit for fitting†, because today benches would be placed randomly around the store for everyone to sit on. There is a separate room â€Å"for very important customers†, but today they would use the benches, the same as everyone else, or go to a different store. Another clue would be the door leading to the house, implying that the Hobsons live there, which is not so commonly practiced today. If these were not enough clues, the objects inside the shop all suggest late 19th century; for example, â€Å"the gas brackets in the windows and walls†, and â€Å"the clogs on exhibit in the windows†. Alice and Vickey's actions and dress also suggest a late 19th century setting, as Alice, only 23, is knitting – not an activity which is commonly pursued by the modern young woman – and the pair are wearing aprons for working in a shoe shop. Although Hobson's Choice consists of four Acts, each of these is comprised of several little scenes. Although these are not official, Brighouse has made it obvious that they are there, and they are often marked by the entrance and exit of a character. Brighouse teaches the audience a lot about his characters in the first Act, and he sets up their personalities and roles to make it easier to digest when their true functions are revealed, and right from the beginning of the play, Brighouse gives the audience an idea as to what the characters of Hobson and his three daughters – Maggie, Alice and Vickey – are like. Maggie is a bossy, moody character, and Brighouse uses the first scene to introduce this to the audience in a conversation between her and Alice; the audience can grasp these characteristics in Maggie from her sharp, snappy response to Alice. For example; â€Å"Alice: I hoped it was father going out. ‘†Maggie: It isn't†. Maggie is very blunt and matter-of-fact when she is talking to her sisters, as she proves again when she says â€Å"He got up late†, in response to another statement from Alice about their father. Brighouse has chosen subtle, yet effective, methods in broadening the audience's knowledge of the characters in Hobson's Choice early in the play, and the characters of Maggie, Alice and Vickey are no exception to this. From the fact that Maggie is reading an account book, whilst Alice and Vickey are knitting and reading, the audience know instantly that Maggie is the one bothered about the business out of the three of them, and that Alice and Vickey would probably rather be out doing other things. Maggie is blunt in every aspect of her life, and it is traits like this found in all of the characters in Hobson's Choice that adds to the play's honesty – none of the characters are perfect, but they do try their best to use their flaws and traits to their advantage. Brighouse uses a metaphor to show Maggie's bluntness in a conversation between Maggie and her two sisters. Maggie says â€Å"See that slipper with a fancy buckle on it to make it look pretty? Courting's like that my lass. All glitter and no use to nobody†, and this sums up what Maggie thinks about marriage, love and life. In terms of marriage and love, Brighouse is telling the audience that Maggie doesn't want to date somebody first, she just wants to marry them. Also, she is not interested in a fancy man, with expensive clothes, lots of money and good looks as it is â€Å"only glitter†; she would rather find somebody genuine, marry him, and then get to know him. Already, Brighouse is building reason for why Maggie would want to marry a man such as this, so the audience can look back on this, and it will help them to understand why Maggie and Willie, at first glance such an unlikely couple, are together. Again, the fact that Maggie is very honest in how she speaks helps to convey the way that Brighouse has created such an honest view of family life. As the audience have already learnt, Maggie is very bossy, and so Brighouse has used the next scene to confirm this. It also introduces Albert, so that the audience know that he likes Alice, and to introduce the shop, and show the audience that Vickey and Alice are not interested in it. The scene shows Maggie confronting Alice's boyfriend, Albert Prosser. They all know why Albert has gone come into the shoe shop – to visit his ‘girlfriend', Alice – but they all put on a front, and act like he is a normal customer coming in to buy some boots; it becomes clear that Albert really does not want to purchase anything. Maggie, however, keeping up the pretence that Albert has come in to actually shop, starts forcing Albert to buy something, so he pretends that he has come in for some shoe laces. To his surprise, Maggie asks Albert, â€Å"What size do you take in boots?†, to which he innocently answers, â€Å"Does that matter to the laces?†. Albert does not realise what Maggie is getting at, until Maggie replies, â€Å"It matters to the boots†, and before he knows it, Albert is being pushed down into one of the seats and having his boots taken off and replaced with new ones. Brighouse also impresses early that Alice and Vickey are very fashionable, which Hobson is not very keen on; he wants his daughters to look nice but smart and ladylike. For example, Vickey and Alice â€Å"had new dresses on last week†, which shows that they want to look good, but Hobson says â€Å"I like to see my daughters look nice. That's why I pay Mr Tudsbury, the draper, à ¯Ã‚ ¿Ã‚ ½10 a year a head to dress you proper. It pleases the eye and it's good for the trade†. Clearly he doesn't like his daughters parading around making fools of themselves and him, which is exactly what he thinks they are doing by dressing like that. Brighouse shows this again, when Hobson euphemises â€Å"You were going down Chapel Street with a hump added to nature behind you†, which shows that he is uncomfortable with the situation and the way his daughters are dressing, as he is playing around with what he wants to say, because he does not know quite how to say it. Later in this conversation between Hobson and his two youngest daughters, Alice says â€Å"it is not immodest, father. It's the fashion to wear bustles†, which shows that Alice and Vickey are fashionable, but their father is not concerned by this, only that they are dressing in this manner, which he describes as â€Å"uppishness† â€Å"the occupation of fools and such as have no brains†. This conversation also shows the age gap between Hobson and his daughters, and the fact that Alice and Vickey are still being controlled by their father, despite the fact that they are 23 and 21, links with one of the themes of the play – the role of women in society. With reference to the title, this is a great example of the typical, honest situations that Brighouse has used throughout Hobson's Choice, which is why it is such an honest, realistic play. It is because the characters and the situations that they find themselves in are so realistic that the play comes across as so honest. Straight away, Brighouse also lets the audience know that Hobson likes a drink, which is something that features throughout the play. Brighouse does this by introducing Hobson through his daughters, where they discuss that he has a hangover from a Mason's Meeting the previous evening. Again, this is another honest situation, and one which makes Hobson's Choice that bit easier for the audience to relate with and to connect to. If the play was not honest, the audience would not be able to relate with the characters or their situations. The audience can also tell that the girls are scared of their father, as they don't seem to be able to do anything until he is gone, for fear that he will tell them off, despite the fact that they are 21, 23 and 30. One example of this is that Alice says she is expecting someone, which is clear to the audience is a man she is courting, but she does not want her father to know that she is courting. One reason why the play is so honest and easy to believe is the way Brighouse has delicately crafted and evolved his characters, allowing the audience to feel a strong relationship between themselves and the characters. An excellent example of this is the character of Willie. At the start of Act One, Willie seems a very timid character – he knows he's neither clever nor important, and this comes across in both his attitude and his behaviour. For example, when talking to Mrs Hepworth, she says, â€Å"Take that†, to which Willie â€Å"bends down rather expecting ‘that' to be a blow†, so rather than stand up to her when he is expecting to be hit, Willie cowers out of the way, but he â€Å"finds she is holding out a visiting card†. Willie is very quick to do as he is told, and Brighouse demonstrates this to the audience on the first occasion that we meet this character. In this scene, Mrs Hepworth wants to see Willie; Tubby just had to call Willie's name down the trap door and he appeared instantly. It is clear to the audience that Willie is a talented boot maker, as Mrs Hepworth is so pleased with her boots that she asks specifically to see Willie, so that she can â€Å"praise him to his face†. However, it seems at this point in the play that boot making may be his only talent, as when Mrs Hepworth instructs Willie to read the card she has given him, it is revealed that he can't even read properly. Willie is dominated by everyone, including not just Mrs Hepworth, but also Maggie, Hobson, Ada, Alice and Vickey. Brighouse uses the dominant character of Maggie to help Willie come out of his shell, and helps him both socially and intellectually, and Brighouse turns Willie into a much stronger and more dominant character, not unlike Maggie herself. The transformation of Willie includes him becoming able to stand up for himself, speak his mind and Maggie even teaches him to read; he stands straighter, taller, holds his head high, looks people in the eye, speaks with a stronger, more confident voice, learns to speak his mind, is much more confident in his abilities and even dresses smarter. An example of him becoming a stronger character and standing up for himself is when he tells Hobson â€Å"Don't let us be too long about this. You've kept me waiting now a good while and my time's valuable. I'm busy at my shop†. This sounds like something Maggie would say, and without pausing for breath Willie manages to put Hobson in his place, and let him know that Willie means business. Another example is where Willie tells Hobson â€Å"You've no right to expect I care whether you sink or swim†, which actually makes Willie out to be quite a nasty character, but Maggie points out that he is going a bit too far. This â€Å"abuse of power† shows that Willie is new to being able to tell people what to do, and he is playing around trying to find his boundaries. Another reason why Hobson's Choice is so honest and easy to believe is because Brighouse has made the focus of the play the characters rather than any individual action or event, which means that the audience can really relate to and sympathise with the characters. It is for this reason that all of the characters in Hobson's Choice have a function; they are all there for a reason to support the roles of the central five – Hobson, Maggie, Willie, Alice and Vickey. Jim Heeler is there for Hobson to confide in, so the audience all know what he is really thinking and what he is going to do next. Mrs Hepworth – the only real customer in the play – is used to introduce the character of Willie, and also later finances Willie and Maggie's business. Ada Figgins's brief appearance shows the contrast the Maggie represents to Willie. Tubby is used later on to show the deterioration of Hobson's business. Albert Prosser and Fred Beenstock are used to help Maggie in plotting against her father. Finally, Dr MacFarlane effectively sets up the final confrontation between Maggie, Willie and Hobson by prescribing Hobson with the necessary cure for his diagnosed weaknesses. Brighouse has cleverly disguised these character's functions by giving them a more direct reason to appear when they do. Heeler appears as Hobson's friend, whilst Mrs Hepworth is first introduced as a customer. Ada, obviously, comes into the shop to bring Willie his lunch, and is then somewhat dumped by Willie in the process! Tubby is the other worker at Hobson's boot shop, and Albert and Fred are Alice and Vickey's boyfriends. Finally, Dr MacFarlane appears simply to diagnose Hobson. This multi-functioning allows Brighouse to create a realistic play, as the characters seem to be innocent at first glance, yet the play soon subtly reveals their true functions. Not only is Hobson's Choice such an honest and realistic play, but it also has a lot of comic elements. The play is often referred to as a â€Å"Lancashire comedy†, as the language and dialect plays a big part in the play's comical elements and the tone of the play. The dialect is informal, and characters often speak using slang words and phrases, such as â€Å"our Maggie†, 'em†, â€Å"aye† and â€Å"eh?† The character's credibility stems from the realistic, naturalistic manner in which they speak. An example of this is Willie's final, defiant speech at the end of Act One. The sharpness of the dialogue itself would be a source of humour, but it forms a constituent part of the greater comedy arising from the interaction between Willie, Hobson and Maggie. This scene between these three characters is just an example of the humour that Brighouse has included within Hobson's Choice. Another particularly entertaining element of Hobson's Choice is a conversation between Maggie and Willie. Maggie asks Willie, â€Å"When are you going to leave Hobson's?† to which Willie replies, â€Å"Leave Hobson's? I – I thought I gave satisfaction†. This is comical as Willie is shocked because he thinks that Maggie is wanting rid of him. The comical element continues when Maggie, in the same conversation, tells Willie that she is going to marry him. The audience would find this entertaining for several reasons; first Maggie is not asking Willie to marry her, she is telling him that he is going to, and the fact that a woman is telling a man what to do, especially something as serious as this, is comic. Also, for Maggie, the daughter of Hobson, the shop owner, to want Willie, a mere worker at her father's shop, to marry her is comical in itself. It is also funny because Maggie is insulting Willie and acting like she thinks that she is better than him, yet she i s demanding to marry him! Another way memorable comic event is when Maggie tells Ada that she is going to marry Willie. This allows Brighouse to entertain the audience by overturning the convention in drama of two men fighting over a woman by showing Maggie and Ada battling for Willie. This event is also comic as neither Willie nor Ada have any say or control over the situation, despite the fact that 10 minutes previous, Maggie had nothing to do with Willie's social life at all! Another comic situation presented in Hobson's Choice is later on in the play, where Hobson's daughters – previously scared of Hobson – are dictating to him what he is going to do, and they, together with Maggie and their partners manage to trick Hobson into handing them over à ¯Ã‚ ¿Ã‚ ½500 for Alice and Albert's wedding! What makes this even more comical is that Maggie manages to convince Hobson that it is he who has won, because he only had to give the couple à ¯Ã‚ ¿Ã‚ ½500 and not à ¯Ã‚ ¿Ã‚ ½1000! Overall, I think that Brighouse has created a very honest view of family life, and the audience will really appreciate this. He has created a naturalistic setting, which requires no interaction or imagination from the audience to enhance the play, so the audience are a fourth wall audience, which is the contemporary equivalent of a modern audience watching a television soap. Brighouse has enhanced the play with regular comic moments to keep the audience engaged and entertained. The comic episodes are more amusing to a contemporary audience as a lot of them are based around contemporary views and beliefs, such as a woman of 30 being too old to marry, therefore it would be harder for a modern audience to appreciate all of the comedy as well as a contemporary audience, but it is these contemporary views that are conveyed in the play that makes it so honest and realistic.

The Rhetorical Strategies of the Scarlett Letter

Grayce Byrnes Mr. Smith AP English 11-Period A 24 September 2012 The wrath of gather In the novel The sanguine Letter, Nathaniel Hawthorne depicts the hardships of a young girl named Hester coerce to live with the earn A pinned to her chest in penitence for her sins in a strict prude town in the 1800s. The illegitimate daughter of Hester carries the same traits and qualities as Hester, making driblet a retroflex of Hester. Hawthorne congeals drib with his use of abridgment diction, queer tone, and his selection of detail.Pearls levelt functions in the beginning as a symbolic character that stands for her mother and the red letter. Pearl becomes the ruby-red Letter brought to manners. She is dressed in elaborate, rubicund garb as if to be a real-life scarlet letter. The narrator explains her as the scarlet letter in another strain the scarlet letter endowed with life (Hawthorne 57). When Hester tries to discard the letter, she gets in a consternation mode, as if H ester is actu bothy discarding her. The author never really states the purpose of Pearl world the scarlet letter, besides instead uses abstract ideas and prodigious vocabulary.Many people in the Puritan community believe that since Hester would not dampen the childs father, that he mustiness be the devil himself. Pearl has an uncanny perception of what goes on around her and continuously is seeking for the equity. The connection of Pearl to the letter and her constant obsession with finding law leads us to believe that the letter subject matter truth. Her excessively perceptive knowledge is around supernatural. Hawthornes tone is one of a whimsical, mischievous, and capricious descriptions. Pearls primary(prenominal) purpose seems to be to uncover the truth for the main characters.Once she completes her goal, A spell was broken. The bully scene of grief, in which the wild baby bore a party, had developed all her sympathies and as her tears fell upon her fathers cheek, th ey were the pact that she would grow up amid human happiness and sorrow, nor forever do battle with the world, but be a woman in it. Towards her mother, too, Pearls errand as a messenger of pain was all fulfilled(233). Her capricious emotions and the fickle opinions of the author make it hard for the reader to decipher if the child is the evil flesh of Hesters sin or vindicatory the naivety and curiosity of a child.Overall, there are some striking similarities in the midst of Hester and Pearl. Even during Hesters pregnancy, she could feel Pearls wild, desperate, defiant mood, the flightiness of her temper, and even some of the very cloud-shapes of gloom and despondence that had brooded in her heart (50). These emotions correlate with Hester. Her wild, desperate and defiant mood is emulated through her treachery of the puritans through her sin. Her temper, gloom, and despondency is felt from Hester because of her labored isolation from the rest of the town and marked a s an outcast. Pearl is described as beautiful, imaginative, graceful, and impulsive.These traits are also seen in Hester. Pearl is a character of mystery and has an to the highest degree supernatural essence to her. The author negotiation about her like she is more than human although we never know if she heaven-sent or from the devil because the author plays both sides of the argument. Pearl is a symbol of the passion that is indoors every human heart, and as the bosh ends with her finding great success in Europe, she shows us that society should never define you. I Pledge My Honor That I Have not Received aid on this Paper _____________________________________________

Prejudice, Stereotyping, and Discrimination Essay

Women and men use stereotypes to create sense of the planet.† (Feenstra, 6. 1 Prejudice, stereotypes, logical and discrimination, para 1). Prejudice is a negative belief or feeling (attitude) about a particular group of individuals. Prejudices can be passed on from one generation to the next.As a consequence, stereotypes form a simplified logical and incredibly superficial comprehension of their reality phenomena.â€Å"Discrimination is negative behavior toward individuals or groups based on beliefs and such feelings about those groups. A group you are a part of is called your ingroup. Ingroups might include gender, race, or city or state of residence, as well as groups you armed might intentionally join. A group you are not a part of is called your outgroup.

There are just twenty two minor kinds of discrimination.The world was a changing place; many times, we saw and heard prejudice, stereotyping, and discrimination at its worst. Unfortunately, we are seeing the same types of prejudices, stereotyping, and discrimination going on today; especially since the â€Å"9-11† attacks and with the â€Å"Occupy or 99%† movement going on today. Social identities depend on the groups to which people belong.Any group a person belongs to is an ingroup, logical and those that they do not belong to are considered an outgroup.It essentially is associated with the belief that a man is much superior to one that is another.And outgroup homogeneity bias blinds us to the differences within the outgroup. † (Feenstra, 6. 1 Social Cognitive origins of prejudice and stereotypes, para 2). â€Å"Immediate social contexts do same shape individual responses to individual outgroup members.

Prejudice doesnt rely with people.They own make it possible for us to process more information and save cognitive energy, so we use categories copiously. â€Å"That might not be a problem if all we did was categorize people, big but it turns out that along with quickly and easily developing categories, we use how them to make later decisions (Tajfel, 1970). † (Feenstra, 2011, 6. 2 Categorization, para.It contributes to discrimination.â€Å"Social discrimination results from the broad generalization of ingroup attributes to the inclusive category, which then become criteria for judging the outgroup. Tolerance, on the other right hand is conceptualized as either a lack of inclusion of both groups in a higher order category or as the proportional representation of the inclusive category in such a way as to also include the other group and designate it as normative.† (Mummendey & Wenzel, 1999, P. 158).

It could be spread by the use of propaganda.d. , P. 10). Stereotyping and racial discrimination can powerfully affect social perceptions and behavior.Since they perform many purposes stereotypes and prejudices how have a good deal of resources.d. , P. 19).Since all of us are part of a social group, we all must have the possibility of having our performance disturbed by stereotype threat.

Competition for funds may additionally fresh produce bias.d. , P. 11). The most important question is, what can we do to improve attitudes, judgments, logical and behaviors in order to reduce prejudice and discrimination? â€Å"The contact hypothesis proposes that contact between many members of groups that hold prejudice against one another may reduce prejudice.Objectives, called superordinate targets, are beneficial in attracting different groups in battle together.Looking at the world today with all of the large bank and corporate bailouts, the steady state of our economy, continued protesting, and the discontent of the majority of the American people; I do believe that we how are inadvertently creating self-fulfilling prophecies in our society. In Self-Fulfilling Prophecies, Michael Biggs states, â€Å"A theory of american society could, in principle, prove self-fulfilling.Marxism predicts that capitalism is fated to end in revolution; if many people believe in the theory , then they could forment revolution (Biggs, 2009). † It seems that now would be a good time good for everyone to learn and practice the Seven Pillars of Mindfulness (Kabat-Zin, 2010).

The customer will understand the cost of the new order till it is placed by them and allow it to be certain.6 Conclusion). References Biggs. M. (2009).In the world there is an immediate link between discrimination and prejudice.uk/~sfos0060/prophecies. pdf Feenstra, J. (2011). Introduction to social psychology.

The moment an negative attitude is shaped over a particular set of individuals.Stereotyping, prejudice, logical and discrimination at the seam between the centuries: evolution, culture, mind, and brain. European new Journal of Social Psychology (30), 299-322. Retrieved from http://www2. psych.Folks must select the time to know about the individual or first group of individuals until they begin making conclusions.Mindful Attitudes. Retrieved from http://mindfulworkshops. com/? tag=non-judging. Mummendey A.

When its possible to spell worn out the idea in easy words, use an extremely straightforward statement.3, No. 2, 158-174. Retrieved from http://dtserv2. compsy.Three other theorists ideas play a important part in the movie.(n. d. ). The psychology of prejudice, stereotyping and discrimination: An overview.

In non violence issues resulting In this, and at times crime, aroused.Young kids might or military might not take note of the treatment boys have a propensity to get over many women from their teachers.What might be a history of the individual to an summary of the, likewise.Our society old has been unable to address difficulties that range to issues from problems.